Thu. Feb 22nd, 2024
Modafinil

Modafinil Online Australia is an oral medication that is use to treat narcolepsy and sleep disco. It is an excellent choice for people with narcolepsy who want to control their excessive daytime sleepiness. It is also available for other conditions such as obstructive sleep apnea and shift work disorder.

The drug can interact with some drugs. Check the patient information leaflet for details. The doctor will determine the best dosage for you.

Narcolepsy

Modafinil is the first nonamphetamine and nonmethylphenidate agent approved for the treatment of excessive daytime sleepiness in narcolepsy. It was shown to be efficacious in two randomized placebo-controlled, nine-week trials in over 550 patients. It also has a favorable safety profile in long-term open-label extension studies. It is a selective wakefulness-promoting agent with no significant catecholamine or dopamine antagonist activity.

It is prescribed for narcolepsy, shift work disorder, and obstructive sleep apnea/hypopnea syndrome (in combination with breathing devices or other therapies to treat the underlying obstruction). It is used alone or in combination with psychosocial therapy.

The most common side effects of Modafinil 200 are headache and nausea. These symptoms are typically mild to moderate and usually go away with continued use. In some cases, Modafinil can cause a rare, severe side effect of ventricular arrhythmia. This is a condition that can be fatal in certain people.

Modalert Tablet is metabolize by the liver and excrete in urine. The active ingredient is eliminate about 15 hours after ingestion. It is recommended that patients with renal or hepatic impairment take smaller doses to achieve the desired therapeutic response.

Obstructive sleep apnea

Obstructive sleep apnea is cause by a natural relaxation of the muscles in the throat and mouth during sleep, which can block or close the airway and interfere with breathing. This can lead to a feeling of choking or smothering and causes a constant snoring sound. In addition to being a common cause of daytime sleepiness, obstructive sleep apnea can also lead to a variety of other symptoms, including headaches, fatigue, concentration problems, and memory loss.

Modafinil 200 promotes wakefulness and improves objective measures of daytime alertness, in a dose-dependent manner. Its effectiveness has been demonstrate in multiple double-blind placebo-controll studies lasting 12 weeks. The most common adverse reactions to modafinil are headache and nausea, but they are usually mild or moderate in severity and respond to treatment.

This medication should not be take by individuals with a history of coronary artery disease, heart valve problems, or hypertension, who may be at risk for heart attack or stroke. It should also not be take by adolescents younger than 17 years of age. This medication interacts with many other medications, so be sure to tell your doctor about all the medicines you are taking.

Shift work disorder

Modafinil ( Modvigil 200 mg ) is a stimulant medication that can help increase wakefulness in people with sleep disorders such as narcolepsy and obstructive sleep apnea. It also can help improve wakefulness during jet lag. It is available as 100-mg and 200-mg oral tablets. Provigil increases the ability to stay awake compared with placebo in clinical trials.

It is not know how modafinil works to increase wakefulness, but it is thought that it affects the brain’s chemicals that control the sleep/wake cycle. It is not use to treat fatigue or make up for lack of sleep in people without a sleep disorder.

During clinical trials, both Modawake 200 and modafinil have improved wakefulness compared to placebo in patients with shift work sleep disorder and other sleep disorders such as narcolepsy or obstructive sleep apnea.

These medications are not effective in people with psychiatric disorders such as psychosis, depression, mania, or major anxiety and may cause a worsening of symptoms such as hostility, agitation, Tourette’s syndrome, or hypnagogic hallucinations.

In addition, they should not be take by people taking antidepressants such as amitriptyline (Elavil), amoxapine (Anapsid), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan) and tricyclic antidepressants such as clomipramine (Clomicalm), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar) and tranylcypromine (Parnate); or antipsychotics such as haloperidol (Haldol) and clozapine (Clozapine). The effectiveness of these medications in children is unknown.

Cataplexy

Cataplexy is a sudden loss of muscle tone that can be trigger by a wide range of emotions, from happiness and laughter to sadness and fear. While rare, this symptom can have serious consequences for those living with narcolepsy. It can affect one or more muscles and can lead to tripping, falling, and even head trauma.

However, unlike other conditions like fainting or seizures, cataplexy is a conscious episode that occurs in people who are awake and aware of what’s happening. The drug modafinil ( Waklert 150 mg ) is effective in treating this symptom, but only after an evaluation of the underlying condition.

The most common cause of narcolepsy with cataplexy is a loss of brain cell that make orexins, which are chemical messengers use by neurons in the hypothalamus to help regulate sleep and wake times. However, the exact mechanism is not fully understood.

A recent study show that adding a 200-mg dose of modafinil at midday to the once-daily morning dose was well tolerate and prolonger wakefulness in narcolepsy patients who experience late afternoon or evening sleepiness despite satisfactory earlier daytime responses to their once-daily medication regimens.

Sleep paralysis

The primary pharmacological activity of Modafinil is its ability to increase wakefulness. It is a member of the benzhydryl sulfinyl acetamide family and is chemically and pharmacologically distinct from stimulants such as dextroamphetamine and methylphenidate. Its action is independent of dopamine and serotonin reuptake inhibition.

Narcolepsy is characterize by excessive daytime sleepiness, cataplexy. Disrupte nocturnal sleep, and sleep paralysis (paralysis of voluntary muscle movement during onset or emergence from sleep). It affects 2-10 people per 10,000 and has a gradual onset of symptoms in childhood. The disorder can lead to poor performance at work or school and is associate with mood disturbances.

In a series of large, double-blind clinical trials, once-daily doses of 200 to 400 mg of Modafinil significantly improved objectively measured sleep latency and waking duration as well as subjectively assessed levels of sleepiness (ESS) compared with placebo.

In the case of narcolepsy, higher doses may be necessary for patients with severe daytime sleepiness. In these cases, the drug can be take once daily in the morning or divide into morning and midday doses. During controll and open-label studies of narcolepsy, obstructive sleep apnea, and shift work disorder. The drug was generally well tolerate and caused few adverse reactions. Read More Blog…